Pacritinib is used to treat myelofibrosis in adults.
Pacritinib may also be used for purposes not listed in this medication guide.
uses
What is Vonjo (Oral) used for?
- Myelofibrosis
warnings
What is the most important information I should know about Vonjo (Oral)?
Some drugs should not be used with pacritinib. Your treatment plan may change if you also use:
- nefazodone;
- St. John's wort;
- an antibiotic–clarithromycin, rifabutin, rifampin, rifapentine, telithromycin;
- antifungal medicine–itraconazole, ketoconazole;
- antiviral medicine for HIV or hepatitis C–boceprevir, cobicistat, dasabuvir, elvitegravir, indinavir, lopinavir/ritonavir, nelfinavir, ombitasvir, paritaprevir, saquinavir, telaprevir, tipranavir;
- cancer medicine–apalutamide, enzalutamide, mitotane;
- seizure medicine–carbamazepine, oxcarbazepine, phenytoin, primidone; or
- steroid medicine–dexamethasone, prednisone.
Tell your doctor if you have ever had:
- liver or kidney disease;
- any other cancers;
- a blood clot, or stroke;
- a heart attack, or other heart problem;
- if you have an infection;
- if you have diarrhea (or loose stools), nausea or vomiting;
- if you smoke or were a smoker; or
- if you have active bleeding, have had severe bleeding, or plan to have surgery.
It is not known if pacritinib will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It may be harder for you to get a woman pregnant while you are using this medicine.
Do not breastfeed while using this medicine, and for at least 2 weeks after your last dose.
User Reviews & Rating
No ratings yet for Vonjo (Oral)
Leave a Review
Side Effects
What are the side effects of Vonjo (Oral)?
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
- bleeding, bruising, and fever;
- severe or ongoing diarrhea;
- dizziness, a light-headed feeling, like you might pass out;
- signs of a stroke–sudden numbness or weakness, severe headache, slurred speech, problems with vision or balance;
- signs of a blood clot in the lung–chest pain, sudden cough or shortness of breath, dizziness, coughing up blood;
- signs of a blood clot deep in the body–pain, swelling, or warmth in one leg;
- heart attack symptoms–chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating; or
- signs of infection–fever, chills, sore throat, body aches, unusual tiredness, loss of appetite, bruising or bleeding.
Common side effects may include:
- swelling in ankles, legs, and feet;
- nausea and vomiting; or
- pale skin, tiredness, feeling light-headed or short of breath, cold hands and feet.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Pregnancy & Breastfeeding
Can I take Vonjo (Oral) if I’m pregnant or breastfeeding?
It is not known if pacritinib will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
Do not breastfeed while using this medicine, and for at least 2 weeks after your last dose.
Interactions
What drugs and food should I avoid while taking Vonjo (Oral)?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Dosage Guidelines & Tips
How to take Vonjo (Oral)?
Use Vonjo (Oral) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
If you take other kinase inhibitors such as fedratinib or ruxolitinib you should not stop using these medicines suddenly before you start taking pacritinib. Follow your doctor's instructions about tapering your dose.
Pacritinib is usually taken by mouth twice every day with or without food.
Swallow the capsule whole and do not crush, chew, break, or open it.
You will need blood tests before you start taking pacritinib and during treatment.
Your treatment with pacritinib may be delayed or permanently discontinued if you have certain side effects.
Store at room temperature away from moisture, heat, and light.
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
Overdose Signs
What happens if I overdose on Vonjo (Oral)?
(800) 222-1222
911
Images
Pacritinib 100 mg, C78837
Color: gray/red
Shape: capsule
Imprint: Pacritinib 100 mg, C78837