Valrubicin is used to treat bladder cancer that has not spread to other parts of the body.
Most people do not have a complete response to this medicine. You may eventually need surgery to remove your bladder to keep the cancer from becoming metastatic (spreading to other parts of your body).
Valrubicin may also be used for purposes not listed in this medicine guide.
uses
What is Valstar (Valrubicin) used for?
- Urinary Tumor
warnings
What is the most important information I should know about Valstar (Valrubicin)?
You should not be treated with valrubicin if you are allergic to it, or if you have:
- a urinary tract infection;
- bladder perforation (a hole or tear); or
- an allergy to polyoxyl castor oil, or to other cancer medicines (daunorubicin, doxorubicin, epirubicin, idarubicin, mitoxantrone).
Tell your doctor if you have ever had:
- overactive bladder, incontinence or leakage;
- bladder surgery; or
- trouble holding a large amount of urine in your bladder.
It may be harder for you to get a woman pregnant while you are using this medicine. You should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.
Valrubicin can harm an unborn baby if the mother or the father is using this medicine.
- If you are a woman, do not use valrubicin if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose.
- If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.
- Tell your doctor right away if a pregnancy occurs while either the mother or the father is using valrubicin.
Do not breastfeed while using this medicine, and for at least 2 weeks after your last dose.
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Side Effects
What are the side effects of Valstar (Valrubicin)?
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
- blood in your urine or painful urination lasting for longer than 24 hours;
- pain or burning when you urinate; or
- low white blood cell counts (about 1 week after a valrubicin injection)–fever, mouth sores, skin sores, sore throat, cough, trouble breathing.
Common side effects may include:
- red or pink urine within the first 24 hours after you receive valrubicin;
- increased urge to urinate, urine leakage;
- painful or difficult urination;
- bladder pain;
- increased urination at night; or
- nausea, stomach pain.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Pregnancy & Breastfeeding
Can I take Valstar (Valrubicin) if I’m pregnant or breastfeeding?
Do not breastfeed while using this medicine, and for at least 2 weeks after your last dose.
Interactions
What drugs and food should I avoid while taking Valstar (Valrubicin)?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Dosage Guidelines & Tips
How to take Valstar (Valrubicin)?
Use Valstar (Valrubicin) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Valrubicin is injected directly into the bladder using a catheter inserted into the urethra (the tube for passing urine out of your bladder). A healthcare provider will give you this medicine, usually once per week for 6 weeks.
Valrubicin is usually given in a solution that amounts to about 2.5 ounces (1/3 cup). This entire amount is injected into the bladder and should be held in for 2 hours. Avoid using the bathroom during this time.
Tell your doctor if you have trouble holding in the medicine for the full 2 hours.
If this medicine accidentally gets on your skin, wash it thoroughly with soap and warm water.
Your will need frequent urine tests, and you may also need a bladder biopsy or a bladder exam using a scope.
Drink plenty of water after each time you receive valrubicin.
You may not have a complete response to valrubicin. After 3 months of treatment without response, your bladder may need to be surgically removed. This can help prevent your cancer from spreading to other parts of your body. Metastatic bladder cancer is usually fatal.
Call your doctor for instructions if you miss an appointment for your valrubicin injection.
Overdose Signs
What happens if I overdose on Valstar (Valrubicin)?
Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely but may cause worsening bladder symptoms.
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