Trilaciclib is used to help prevent bone marrow suppression in people receiving chemotherapy with certain medicines to treat small cell lung cancer.
Trilaciclib may also be used for purposes not listed in this medication guide.
uses
What is Trilaciclib (Cosela) used for?
- Chemotherapy Toxicity
warnings
What is the most important information I should know about Trilaciclib (Cosela)?
You should not be treated with trilaciclib if you are allergic to it.
Tell your doctor if you have ever had liver problems.
Trilaciclib may harm an unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 3 weeks after your last dose. Tell your doctor if you become pregnant.
You should not breastfeed while using trilaciclib and for at least 3 weeks after your last dose.
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Side Effects
What are the side effects of Trilaciclib (Cosela)?
Get emergency medical help if you have signs of an allergic reaction: hives, itching; difficult breathing; swelling of your eyes, face, lips, tongue, or throat.
Call your doctor at once if you have:
- pain, redness, warmth, itching, swelling, bruising, or skin changes where the medicine was injected;
- fever, chills, cough with mucus;
- sudden chest pain, wheezing, dry cough, feeling short of breath;
- low calcium level–muscle spasms or contractions, numbness or tingly feeling (around your mouth, or in your fingers and toes); or
- low potassium level–leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling.
Your trilaciclib treatments may be delayed or permanently discontinued if you have certain side effects.
Common side effects may include:
- low levels of calcium or potassium;
- headache;
- breathing problems;
- feeling tired; or
- abnormal liver function tests.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Pregnancy & Breastfeeding
Can I take Trilaciclib (Cosela) if I’m pregnant or breastfeeding?
Trilaciclib may harm an unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 3 weeks after your last dose. Tell your doctor if you become pregnant.
You should not breastfeed while using trilaciclib and for at least 3 weeks after your last dose.
Interactions
What drugs and food should I avoid while taking Trilaciclib (Cosela)?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Dosage Guidelines & Tips
How to take Trilaciclib (Cosela)?
Use Trilaciclib (Cosela) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Trilaciclib is given as an infusion into a vein, usually within 4 hours before the start of your chemotherapy infusion. A healthcare provider will give you this injection.
Trilaciclib must be given slowly, and the infusion can take at least 30 minutes to complete.
Call your doctor for instructions if you miss an appointment for your trilaciclib injection.
Overdose Signs
What happens if I overdose on Trilaciclib (Cosela)?
Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
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