Tranylcypromine (Parnate) – Side Effects, Interactions, Uses, Dosage, Warnings

Tranylcypromine is a monoamine oxidase inhibitor (MAOI) that works by increasing the levels of certain chemicals in the brain.

Tranylcypromine is used to treat major depressive episodes in adults when other medicines have not been effective.

Tranylcypromine may also be used for purposes not listed in this medication guide.


What is Tranylcypromine (Parnate) used for?

  • Depression
  • Depressive Psychosis
  • Arteriosclerotic Dementia w/ Depressive Features
  • Dementia w/ Depressive Features


What is the most important information I should know about Tranylcypromine (Parnate)?

You should not use tranylcypromine if you are allergic to it, or if you have:

  • pheochromocytoma (tumor of the adrenal gland).

A dangerous drug interaction could occur between tranylcypromine and certain other medications you used in the past 14 days. You should not take tranylcypromine if you also use:

  • other antidepressants;
  • buspirone, carbamazepine, reserpine, tapentadol, tetrabenazine, tryptophan, SAM-e;
  • diet pills, stimulants, ADHD medications, cough and cold or allergy medicines;
  • another MAO inhibitor–isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, and others; or
  • drugs that affect serotonin levels in your body–stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting.

Tell your doctor if you have ever had:

  • heart disease, high or low blood pressure, circulation problems, or a stroke;
  • bipolar disorder (manic depression);
  • liver disease;
  • a thyroid disorder;
  • headaches;
  • diabetes (tranylcypromine may cause low blood sugar); or
  • a seizure.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Tranylcypromine may harm an unborn baby. Tell your doctor if you are pregnant or if you become pregnant.

You should not breast-feed while using tranylcypromine.

Tranylcypromine is not approved for use by anyone younger than 18 years old.

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Side Effects

What are the side effects of Tranylcypromine (Parnate)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

  • dilated pupils, vision problems, sensitivity to light;
  • sudden and severe headache, neck pain or stiffness;
  • numbness or weakness, problems with vision or speech;
  • fast or pounding heartbeats;
  • fever, cold sweat, nausea, vomiting;
  • a light-headed feeling, like you might pass out;
  • a seizure;
  • manic episodes–racing thoughts, increased energy, decreased need for sleep, risk-taking behavior, being agitated or talkative;
  • high levels of serotonin in the body–agitation, hallucinations, sweating, shivering, muscle stiffness, twitching, loss of coordination, vomiting, diarrhea; or
  • liver problems–loss of appetite, stomach pain (upper right side), dark urine, jaundice (yellowing of the skin or eyes).

Serious side effects may be more likely in older adults.

Common side effects may include:

  • dizziness, drowsiness;
  • constipation;
  • dry mouth, blurred vision;
  • trouble sleeping;
  • headache; or
  • feeling shaky or excited.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Pregnancy & Breastfeeding

Can I take Tranylcypromine (Parnate) if I’m pregnant or breastfeeding?

Tranylcypromine may harm an unborn baby. Tell your doctor if you are pregnant or if you become pregnant.

You should not breast-feed while using tranylcypromine.


What drugs and food should I avoid while taking Tranylcypromine (Parnate)?

Do not drink alcohol. Dangerous side effects could occur.

You must not eat foods that are high in tyramine, including:

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Eating tyramine while you are taking tranylcypromine can raise your blood pressure to dangerous levels, causing life-threatening side effects. Also avoid tyramine for 2 weeks after you stop taking tranylcypromine.

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Dosage Guidelines & Tips

How to take Tranylcypromine (Parnate)?

Use Tranylcypromine (Parnate) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Your blood pressure will need to be checked often.

You may need to stop using tranylcypromine for a short time before any type of surgery or medical procedure. Tell any doctor who treats you that you take tranylcypromine.

It may take a few weeks before you receive the full benefit of taking tranylcypromine. Your doctor will determine how long to treat you with this medicine.

Do not stop using tranylcypromine suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.

Store at room temperature away from moisture and heat.

What should I do if I missed a dose of Tranylcypromine (Parnate)?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

Overdose Signs

What happens if I overdose on Tranylcypromine (Parnate)?

If you think you or someone else may have overdosed on: Tranylcypromine (Parnate),  call your doctor or the Poison Control center

(800) 222-1222

If someone collapses or isn't breathing after taking Tranylcypromine (Parnate), call 911



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