Trandolapril is an ACE inhibitor. ACE stands for angiotensin converting enzyme.
Verapamil is a calcium channel blocker. It works by relaxing the muscles of your heart and blood vessels.
Trandolapril and verapamil is a combination medicine used to treat high blood pressure (hypertension).
Trandolapril and verapamil may also be used for purposes not listed in this medication guide.
uses
What is Trandolapril and Verapamil (Tarka) used for?
- Hypertension
- Pre-eclampsia/Eclampsia
- Cardiovascular Disease
- Hypertensive Congestive Heart Failure
- Hypertensive Heart (w/ CHF) and Renal Disease
- Hypertensive Heart (w/o CHF) and Renal Disease
- Hypertensive Renal Disease
- Hypertensive Retinopathy
- Renovascular Hypertension
- Hypertensive Encephalopathy
- Hypertensive Heart Disease
warnings
What is the most important information I should know about Trandolapril and Verapamil (Tarka)?
You should not use this medicine if you are allergic to trandolapril or verapamil, or if you have:
- certain serious heart conditions, especially "sick sinus syndrome" or "AV block" (unless you have a pacemaker);
- a heart rhythm disorder;
- low blood pressure;
- an allergy to any other ACE inhibitor, such as benazepril, captopril, fosinopril, enalapril, lisinopril, moexipril, perindopril, quinapril, or ramipril; or
- if you also use flibanserin (Addyi).
Do not take trandolapril and verapamil within 36 hours before or after taking medicine that contains sacubitril (such as Entresto).
If you have diabetes, do not use trandolapril and verapamil together with any medication that contains aliskiren (a blood pressure medicine).
You may also need to avoid taking trandolapril and verapamil with aliskiren if you have kidney disease.
Tell your doctor if you have ever had:
- kidney disease (or if you are on dialysis);
- liver disease;
- congestive heart failure;
- diabetes; or
- a nerve-muscle disease such as muscular dystrophy.
Do not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. Trandolapril and verapamil can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.
You should not breastfeed while you are using trandolapril and verapamil.
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Side Effects
What are the side effects of Trandolapril and Verapamil (Tarka)?
Get emergency medical help if you have signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
- a light-headed feeling, like you might pass out;
- upper stomach pain, and jaundice (yellowing of the skin or eyes);
- chest pain, fast, slow, or uneven heart rate;
- high potassium level–nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement;
- kidney problems–little or no urination, swelling in your feet or ankles, feeling tired or short of breath;
- low white blood cell counts–fever, chills, feeling light-headed, mouth sores, skin sores, sore throat, cough, trouble breathing; or
- fluid build-up in or around the lungs–pain when you breathe, feeling short of breath while lying down, wheezing, gasping for breath, cough with foamy mucus, cold, clammy skin, anxiety, rapid heartbeats.
Common side effects may include:
- cough;
- cold symptoms such as stuffy nose, sneezing, sore throat;
- headache, dizziness;
- chest pain, back pain;
- constipation;
- feeling tired; or
- abnormal liver function tests.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Pregnancy & Breastfeeding
Can I take Trandolapril and Verapamil (Tarka) if I’m pregnant or breastfeeding?
Do not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. Trandolapril and verapamil can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.
You should not breastfeed while you are using trandolapril and verapamil.
Interactions
What drugs and food should I avoid while taking Trandolapril and Verapamil (Tarka)?
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.
Do not use potassium supplements or salt substitutes while you are taking trandolapril and verapamil, unless your doctor has told you to.
Dosage Guidelines & Tips
How to take Trandolapril and Verapamil (Tarka)?
Use Trandolapril and Verapamil (Tarka) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Trandolapril and verapamil works best if you take it with food.
Your blood pressure will need to be checked often.
Some things can cause your blood pressure to get too low. This includes vomiting, diarrhea, or heavy sweating. Call your doctor if you are sick with vomiting or diarrhea.
If you need surgery, tell your surgeon you currently use this medicine. You may need to stop for a short time.
Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.
Store at room temperature away from moisture and heat.
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
Overdose Signs
What happens if I overdose on Trandolapril and Verapamil (Tarka)?
Overdose symptoms may include slow heart rate, weak pulse, muscle weakness, tingly feeling, seizure (convulsions), feeling light-headed, or fainting.
(800) 222-1222
911
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