Talazoparib (Talzenna) – Side Effects, Interactions, Uses, Dosage, Warnings

Talazoparib is used to treat HER2-negative breast cancer that has spread to other parts of the body.

Talazoparib is used only if your cancer has a specific genetic marker (an abnormal "BRCA" gene). Your doctor will test you for this gene.

Talazoparib may also be used for purposes not listed in this medication guide.


What is Talazoparib (Talzenna) used for?

  • Breast Cancer
  • Breast Cancer — Male
  • Neoplasia — Estrogen Dependent


What is the most important information I should know about Talazoparib (Talzenna)?

Tell your doctor if you have ever had:

  • kidney disease.

Using talazoparib may increase your risk of developing bone marrow problems or leukemia. Ask your doctor about this risk.

You may need to have a negative pregnancy test before starting this treatment.

Talazoparib can harm an unborn baby or cause a miscarriage if the mother or the father is using this medicine.

  • If you are a woman, do not use talazoparib if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 7 months after your last dose.
  • If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 4 months after your last dose.
  • Tell your doctor right away if a pregnancy occurs while either the mother or the father is using talazoparib.

This medicine may affect fertility (ability to have children) in men. However, it is important to use birth control to prevent pregnancy because talazoparib can harm an unborn baby.

Do not breastfeed while using this medicine, and for at least 1 month after your last dose.

Talazoparib is not approved for use by anyone younger than 18 years old.

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Side Effects

What are the side effects of Talazoparib (Talzenna)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • blood in your urine or stools;
  • easy bruising, unusual bleeding, purple or red spots under your skin;
  • weight loss;
  • low red blood cells (anemia)–pale skin, weakness, feeling tired or short of breath, cold hands and feet; or
  • low white blood cell counts–fever, mouth sores, skin sores, sore throat, cough, trouble breathing.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

  • low blood cell counts;
  • nausea, vomiting, diarrhea, loss if appetite;
  • hair loss;
  • headache; or
  • feeling weak or tired.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Pregnancy & Breastfeeding

Can I take Talazoparib (Talzenna) if I’m pregnant or breastfeeding?

You may need to have a negative pregnancy test before starting this treatment.

Do not breastfeed while using this medicine, and for at least 1 month after your last dose.


What drugs and food should I avoid while taking Talazoparib (Talzenna)?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Dosage Guidelines & Tips

How to take Talazoparib (Talzenna)?

Use Talazoparib (Talzenna) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

You may take talazoparib with or without food.

Swallow the capsule whole and do not dissolve or open it.

If you vomit shortly after taking talazoparib, do not take another dose. Wait until your next scheduled dose time to take the medicine again.

Talazoparib is usually given until your body no longer responds to the medication.

Talazoparib can lower your blood cell counts, and you may get an infection or bleed more easily. You will need weekly or monthly blood tests, and your cancer treatments may be delayed based on the results.

Store at room temperature away from moisture and heat.

You should not stop using talazoparib without first asking your doctor.

What should I do if I missed a dose of Talazoparib (Talzenna)?

Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.

Overdose Signs

What happens if I overdose on Talazoparib (Talzenna)?

If you think you or someone else may have overdosed on: Talazoparib (Talzenna),  call your doctor or the Poison Control center

(800) 222-1222

If someone collapses or isn't breathing after taking Talazoparib (Talzenna), call 911



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