Sotorasib (Lumakras) – Side Effects, Interactions, Uses, Dosage, Warnings

Sotorasib is used to treat non-small cell lung cancer that is advanced or has spread to other parts of the body (metastatic) after treatment with at least one cancer medicine.

Your doctor will make sure you have the correct tumor type to be treated with sotorasib.

Sotorasib may also be used for purposes not listed in this medication guide.


What is Sotorasib (Lumakras) used for?

  • Non-Small Cell Lung Cancer


What is the most important information I should know about Sotorasib (Lumakras)?

Tell your doctor if you have ever had:

  • liver disease; or
  • breathing problems other than lung cancer.

It is not known if sotorasib will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Do not breastfeed while using this medicine, and for at least 1 week after your last dose.

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Side Effects

What are the side effects of Sotorasib (Lumakras)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Sotorasib may cause breathing problems that could lead to death. Get emergency medical help if you have new or worsening fever, cough, or shortness of breath.

Call your doctor at once if you have:

  • severe ongoing nausea, vomiting, or diarrhea; or
  • liver problems–nausea, vomiting, loss of appetite, stomach pain (upper right side), tiredness, bruising or bleeding, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

  • nausea, diarrhea;
  • cough;
  • liver problems;
  • pain in your bones, joints, or muscles;
  • tiredness; or
  • abnormal lab tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Pregnancy & Breastfeeding

Can I take Sotorasib (Lumakras) if I’m pregnant or breastfeeding?

It is not known if sotorasib will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Do not breastfeed while using this medicine, and for at least 1 week after your last dose.


What drugs and food should I avoid while taking Sotorasib (Lumakras)?

Avoid taking a stomach acid reducer, such as:

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If you take an antacid (such as Maalox, Milk of Magnesia, Mylanta, Pepcid Complete, Rolaids, or Tums), take your sotorasib dose 4 hours before or 10 hours after taking the antacid. Use only the type of antacid your doctor recommends.

Dosage Guidelines & Tips

How to take Sotorasib (Lumakras)?

Use Sotorasib (Lumakras) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Take the medicine at the same time each day, with or without food.

You may need to use up to 8 tablets for your entire dose. Follow your doctor's dosing instructions very carefully.

Swallow the tablet whole and do not crush, chew, or break it.

If you cannot swallow a tablet whole, place it into a glass with 4 ounces of plain water. Stir until the tablet is dispersed (it will not dissolve completely) and drink this mixture right away or stir it again and drink it within 2 hours. Do not chew the tablet pieces. Add 4 ounces more water to the glass, swirl gently and drink right away.

If you vomit shortly after taking sotorasib, do not take another dose. Take your next dose as scheduled.

You will need frequent blood tests to check your liver function. Your dose or medication schedule may be changed based on the results.

Store at room temperature away from moisture and heat.

What should I do if I missed a dose of Sotorasib (Lumakras)?

Use the medicine as soon as you can, but skip the missed dose if you are more than 6 hours late for the dose. Do not use two doses at one time.

Overdose Signs

What happens if I overdose on Sotorasib (Lumakras)?

If you think you or someone else may have overdosed on: Sotorasib (Lumakras),  call your doctor or the Poison Control center

(800) 222-1222

If someone collapses or isn't breathing after taking Sotorasib (Lumakras), call 911



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AMG, 120

Color: yellow

Shape: oblong

Form: film coated

Imprint: AMG, 120

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