Sorafenib (Nexavar) – Side Effects, Interactions, Uses, Dosage, Warnings

Side Effects

What are the side effects of Sorafenib (Nexavar)?

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Get emergency medical help if you have symptoms of a heart attack or heart failure: chest pain, fast heartbeats, sweating, nausea, trouble breathing, feeling light-headed, or swelling around your midsection or in your lower legs.

Call your doctor at once if you have:

• fast or pounding heartbeats, fluttering in your chest;
• shortness of breath, sudden dizziness (like you might pass out);
• easy bruising or bleeding (nosebleeds, bleeding gums);
• heavy menstrual periods or unusual vaginal bleeding;
• pain, redness, swelling, rash, blisters or peeling in the palms of your hands or the soles of your feet;
• fever with nausea, vomiting, or severe stomach pain
• a surgical incision or wound that will not heal;
• liver problems–loss of appetite, stomach pain (upper right side), nausea, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
• signs of bleeding inside your body–pink or brown urine, abnormal vaginal bleeding, bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

• bleeding;
• feeling tired;
• vomiting, diarrhea, nausea, stomach pain;
• high blood pressure;
• rash; or
• weight loss, thinning hair.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.