Santyl (Collagenase Topical) – Side Effects, Interactions, Uses, Dosage, Warnings

Collagenase topical (for the skin) is used to treat severe burns or skin ulcers in adults. This medicine helps remove dead skin tissue and aid in wound healing.

Collagenase topical may also be used for purposes not listed in this medication guide.


What is Santyl (Collagenase Topical) used for?

  • Keratosis


What is the most important information I should know about Santyl (Collagenase Topical)?

You should not use collagenase topical if you are allergic to it.

Tell your doctor if you are pregnant or breastfeeding.

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Side Effects

What are the side effects of Santyl (Collagenase Topical)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if your skin condition gets worse, or you have new symptoms of illness or infection.

Less serious side effects may be more likely, and you may have none at all.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Pregnancy & Breastfeeding

Can I take Santyl (Collagenase Topical) if I’m pregnant or breastfeeding?

Tell your doctor if you are pregnant or breastfeeding.


What drugs and food should I avoid while taking Santyl (Collagenase Topical)?

Avoid using other medications on the areas you treat with collagenase topical unless your doctor tells you to.

Dosage Guidelines & Tips

How to take Santyl (Collagenase Topical)?

Use Santyl (Collagenase Topical) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Wash your hands before and after applying collagenase topical.

Carefully follow your medical care provider's instructions about how to clean the skin wound and care for the wound dressing.

Collagenase topical is usually applied once daily. You may need to clean the wound and reapply the ointment if the treated area becomes soiled.

Do not share this medicine with another person, even if they have the same symptoms you have.

The enzymes in collagenase topical may increase your risk of infection in the bloodstream. Call your doctor right away if you have a fever, chills, rapid heartbeats, nausea, vomiting, or diarrhea, or if you feel light-headed or confused.

Store at room temperature away from moisture and heat. Keep the tube tightly closed when not in use.

What should I do if I missed a dose of Santyl (Collagenase Topical)?

Apply the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not apply two doses at one time.

Overdose Signs

What happens if I overdose on Santyl (Collagenase Topical)?

An overdose of collagenase topical is not expected to be dangerous. If you think you have applied too much of this medication, you may wash off the enzyme with povidone iodine.

If you think you or someone else may have overdosed on: Santyl (Collagenase Topical),  call your doctor or the Poison Control center

(800) 222-1222

If someone collapses or isn't breathing after taking Santyl (Collagenase Topical), call 911


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