Amivantamab is used to treat non-small cell lung cancer that has an abnormal "EGFR" gene and has spread to other parts of the body (metastatic) or cannot be removed with surgery. Your doctor will make sure you have the correct tumor type to be treated with this medicine.
Amivantamab is given after other treatments did not work or stopped working.
Amivantamab may also be used for purposes not listed in this medication guide.
uses
What is Rybrevant (Intravenous) used for?
- Non-Small Cell Lung Cancer
warnings
What is the most important information I should know about Rybrevant (Intravenous)?
Tell your doctor if you have ever had lung problems other than cancer.
May harm an unborn baby. You may need a pregnancy test to make sure you are not pregnant. Use birth control while using amivantamab and for at least 3 months after your last dose. Tell your doctor if you become pregnant.
Do not breastfeed while using this medicine, and for at least 3 months after your last dose.
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Side Effects
What are the side effects of Rybrevant (Intravenous)?
Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
Some side effects may occur during the injection. Tell your care provider if you feel nauseated, light-headed, short of breath, chilled or feverish, or if you have chest discomfort.
Call your doctor at once if you have:
- eye pain or redness, itching, watery eyes, sensitivity to light;
- vision changes;
- dark floating spots in your field of vision (floaters);
- skin changes such as acne, itching, or dryness; or
- lung problems (may be similar to symptoms of your cancer)–new or worsening cough, fever, or shortness of breath.
Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.
Common side effects may include:
- a reaction during the injection;
- cough, shortness of breath;
- feeling very tired;
- rash;
- infection of the a skin around your nails;
- swelling anywhere in your body;
- nausea, vomiting, constipation;
- mouth sores;
- joint or muscle pain; or
- abnormal blood tests.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Pregnancy & Breastfeeding
Can I take Rybrevant (Intravenous) if I’m pregnant or breastfeeding?
May harm an unborn baby. You may need a pregnancy test to make sure you are not pregnant. Use birth control while using amivantamab and for at least 3 months after your last dose. Tell your doctor if you become pregnant.
Do not breastfeed while using this medicine, and for at least 3 months after your last dose.
Interactions
What drugs and food should I avoid while taking Rybrevant (Intravenous)?
Amivantamab can cause skin reactions. Avoid sunlight and tanning beds during treatment and for 2 months after your last dose. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
If you have problems with your eyes, avoid wearing contact lenses until your symptoms can be checked by an eye doctor.
Dosage Guidelines & Tips
How to take Rybrevant (Intravenous)?
Use Rybrevant (Intravenous) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Amivantamab is injected into a vein by a healthcare provider, usually every 2 to 4 weeks.
This medicine is injected slowly over several hours.
You may be given other medications to help prevent serious side effects or an allergic reaction. Keep using these medicines for as long as your doctor has prescribed.
You may need frequent vision exams.
May cause rash, itching, and dry skin. Use only alcohol-free cream or lotion to treat dry skin.
Call your doctor for instructions if you miss an appointment for your amivantamab injection.
Overdose Signs
What happens if I overdose on Rybrevant (Intravenous)?
In a medical setting an overdose would be treated quickly.
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