Selpercatinib is used to treat a certain type of non-small cell lung cancer in adults.
Selpercatinib is also used to treat certain types of thyroid cancer in adults and children at least 12 years old.
This medicine is used when the cancer has spread to other parts of the body (metastatic).
Selpercatinib is used only if your cancer has a specific genetic marker (an abnormal "RET" gene). Your doctor will test you for this gene.
Selpercatinib was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, some people responded to this medicine, but further studies are needed.
Selpercatinib may also be used for purposes not listed in this medication guide.
uses
What is Retevmo (Oral) used for?
- Non-Small Cell Lung Cancer
- Thyroid Cancer
warnings
What is the most important information I should know about Retevmo (Oral)?
You should not use selpercatinib if you have untreated or uncontrolled hypertension (high blood pressure).
Tell your doctor if you have ever had:
- liver disease; or
- long QT syndrome (in you or a family member).
Both men and women using this medicine should use effective birth control to prevent pregnancy. Selpercatinib can harm an unborn baby if the mother or father is using this medicine. Keep using birth control for at least 1 week after your last dose.
Tell your doctor right away if a pregnancy occurs while either the mother or the father is using selpercatinib.
This medicine may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because selpercatinib can harm an unborn baby.
Do not breastfeed while using this medicine, and for at least 1 week after your last dose.
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Side Effects
What are the side effects of Retevmo (Oral)?
Get emergency medical help if you have signs of an allergic reaction: hives, rash; fever, joint or muscle pain; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
- easy bruising or bleeding (nosebleeds, bleeding gums);
- coughing up blood or vomit that looks like coffee grounds;
- any wound that will not heal;
- fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out);
- fever, chills, cough with mucus, chest pain, feeling short of breath; or
- liver problems–loss of appetite, stomach pain (upper right side), dark urine, jaundice (yellowing of the skin or eyes).
Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.
Common side effects may include:
- abnormal blood tests;
- high blood pressure;
- tiredness;
- dry mouth;
- diarrhea;
- swelling;
- rash; or
- constipation.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Pregnancy & Breastfeeding
Can I take Retevmo (Oral) if I’m pregnant or breastfeeding?
Do not breastfeed while using this medicine, and for at least 1 week after your last dose.
Interactions
What drugs and food should I avoid while taking Retevmo (Oral)?
Ask your doctor before using any medicine to reduce stomach acid, including an antacid.
Avoid taking an herbal supplement containing St. John's wort.
Dosage Guidelines & Tips
How to take Retevmo (Oral)?
Use Retevmo (Oral) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Selpercatinib is usually taken every 12 hours.
Take selpercatinib with food if you also use a "proton pump inhibitor" stomach acid medicine such as esomeprazole, lansoprazole, omeprazole, Prevacid, Prilosec, Nexium, and others.
Follow your doctor's dosing instructions very carefully.
If you vomit shortly after taking selpercatinib, do not take another dose. Wait until your next scheduled dose time to take the medicine again.
Selpercatinib doses are based on weight (especially in children and teenagers). Your dose needs may change if you gain or lose weight.
You may be given steroid medicine if you have an allergic reaction. Keep using this medicine for as long as your doctor has prescribed.
Your blood pressure will need to be checked often.
If you need surgery, tell your surgeon you currently use selpercatinib. You may need to stop for at least 7 days before a planned surgery.
Store at room temperature away from moisture and heat.
Take the medicine as soon as you can, but skip the missed dose if your next dose is due in less than 6 hours. Do not take two doses at one time.
Overdose Signs
What happens if I overdose on Retevmo (Oral)?
(800) 222-1222
911
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Lilly 2980 80 mg
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Shape: capsule
Imprint: Lilly 3977 40 mg