Relugolix (Orgovyx) – Side Effects, Interactions, Uses, Dosage, Warnings

Relugolix is used to treat advanced prostate cancer.

Relugolix may also be used for purposes not listed in this medication guide.


What is Relugolix (Orgovyx) used for?

  • Prostate Cancer


What is the most important information I should know about Relugolix (Orgovyx)?

Relugolix is not for use in women or children.

Tell your doctor if you have ever had:

  • heart problems; or
  • long QT syndrome (in you or a family member).

Use effective birth control if your sex partner is pregnant or able to get pregnant. Relugolix can harm an unborn baby if the father is using this medicine. Keep using birth control for at least 2 weeks after your last dose of this medicine.

This medicine may affect fertility (your ability to have children). However, it is important to use birth control if your partner is pregnant or able to get pregnant because relugolix can harm an unborn baby.

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Side Effects

What are the side effects of Relugolix (Orgovyx)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out);
  • chest pain or pressure;
  • sudden numbness or weakness on one side of the body;
  • little or no urination, pain or burning when you urinate;
  • breast pain or swelling;
  • depressed mood; or
  • unusual bleeding.

Common side effects may include:

  • flushing (sudden warmth, redness, or tingly feeling);
  • feeling tired;
  • weight gain;
  • impotence, sexual problems;
  • diarrhea, constipation;
  • muscle or joint pain; or
  • abnormal lab tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


What drugs and food should I avoid while taking Relugolix (Orgovyx)?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Dosage Guidelines & Tips

How to take Relugolix (Orgovyx)?

Use Relugolix (Orgovyx) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Relugolix is usually taken as 3 tablets the first day, followed by 1 tablet per day from then on.

Take the medicine at the same time each day, with or without food.

Swallow the tablet whole and do not crush, chew, or break it.

You may need frequent blood tests. Your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG).

Your doctor will determine how long to treat you with relugolix. Do not change your dose or stop using this medicine without your doctor's advice.

Store at room temperature away from moisture and heat. Keep the tablets in their original container, along with the packet or canister of moisture-absorbing preservative.

Keep the bottle tightly closed when not in use.

What should I do if I missed a dose of Relugolix (Orgovyx)?

Use the medicine as soon as you can, but skip the missed dose if you are more than 12 hours late for the dose. Do not use two doses at one time.

If you miss more than 7 daily doses, your doctor may want you to restart the medicine by taking 3 tablets the first day and 1 daily tablet thereafter.

Overdose Signs

What happens if I overdose on Relugolix (Orgovyx)?

If you think you or someone else may have overdosed on: Relugolix (Orgovyx),  call your doctor or the Poison Control center

(800) 222-1222

If someone collapses or isn't breathing after taking Relugolix (Orgovyx), call 911



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R, 120

Color: red

Shape: oval

Form: film coated

Imprint: R, 120

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