Rasagiline is used to treat symptoms of Parkinson's disease (stiffness, tremors, spasms, poor muscle control). Rasagiline is sometimes used with another medicine called levodopa.
Rasagiline may also be used for purposes not listed in this medication guide.
What is Rasagiline (Azilect) used for?
- Parkinson's Disease
What is the most important information I should know about Rasagiline (Azilect)?
You should not take rasagiline if you are allergic to it.
Do not use rasagiline if you have used any other MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, selegiline, tranylcypromine, and others.
Many drugs can interact and cause dangerous effects. Some drugs should not be used together with rasagiline. Your doctor may change your treatment plan if you also use:
- cyclobenzaprine (a muscle relaxer);
- dextromethorphan (contained in many over-the-counter cough medicines);
- meperidine (Demerol);
- St. John's wort; or
- tramadol (Ultram, Ultracet).
Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, migraine headaches, serious infections, or prevention of nausea and vomiting. These medicines may interact with rasagiline and cause a serious condition called serotonin syndrome.
Tell your doctor if you have ever had:
- high or low blood pressure;
- liver or kidney disease; or
- if you take ciprofloxacin (an antibiotic).
People with Parkinson's disease may have a higher risk of skin cancer (melanoma). Ask your doctor about skin symptoms to watch for.
Tell your doctor if you are pregnant or breastfeeding.
What are the side effects of Rasagiline (Azilect)?
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
- severe headache, blurred vision, pounding in your neck or ears;
- extreme drowsiness or falling asleep suddenly, even after feeling alert;
- unusual changes in mood or behavior;
- a light-headed feeling, like you might pass out; or
- worsening symptoms of Parkinson's disease (especially uncontrolled muscle movements).
Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.
Some people taking rasagiline with levodopa have fallen asleep during normal daytime activities such as working, talking, eating, or driving. Tell your doctor if you have any problems with daytime sleepiness or drowsiness.
You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medicine. Talk with your doctor if this occurs.
Common side effects may include:
- depressed mood;
- sleep problems (insomnia), strange dreams;
- involuntary muscle movements;
- loss of appetite, weight loss;
- indigestion, stomach pain, nausea, vomiting, constipation;
- joint pain or stiffness;
- cough or other flu symptoms;
- dry mouth; or
- swelling in your hands or feet.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Pregnancy & Breastfeeding
Can I take Rasagiline (Azilect) if I’m pregnant or breastfeeding?
Tell your doctor if you are pregnant or breastfeeding.
What drugs and food should I avoid while taking Rasagiline (Azilect)?
Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.
Avoid drinking alcohol, especially red wine, vermouth, and tap beers or ale.
Also avoid eating foods that are high in tyramine, such as aged cheeses, fava beans, soy sauce, herring, pickled or processed meats and fish, and meats that are aged, dried, smoked, or fermented. Eating tyramine while you are taking rasagiline can raise your blood pressure to dangerous levels which could cause life-threatening side effects.
Dosage Guidelines & Tips
How to take Rasagiline (Azilect)?
Use Rasagiline (Azilect) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
If you take rasagiline alone, your dose may be different than if you take rasagiline with other Parkinson's medications. Follow your doctor's dosing instructions very carefully.
Rasagiline may be only part of a complete program of treatment that also includes a special diet. Follow the diet plan created for you by your doctor or nutrition counselor.
Get familiar with the list of foods you should avoid to help prevent certain side effects of rasagiline.
Call your doctor if your Parkinson's symptoms do not improve, or if they get worse while using rasagiline.
Store at room temperature away from moisture and heat.
Do not stop using rasagiline suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using rasagiline.
What happens if I overdose on Rasagiline (Azilect)?
Overdose symptoms may include drowsiness, dizziness, severe headache, rapid pulse, feeling agitated or irritable, muscle spasms in your neck or jaw, sweating, cold or clammy skin, shallow breathing, fainting, or seizure (convulsions). These symptoms may be delayed for 12 to 24 hours after an overdose.
Imprint: GIL 0.5
Imprint: GIL 1