Ranexa (Ranolazine) – Side Effects, Interactions, Uses, Dosage, Warnings

Ranolazine is used to treat chronic angina (chest pain). Ranolazine is not for use during an acute (emergency) attack of angina.

Ranolazine may also be used for purposes not listed in this medication guide.


What is Ranexa (Ranolazine) used for?

  • Angina Pectoris
  • Heart Disease
  • Ischemic Heart Disease
  • Prinzmetal's Angina


What is the most important information I should know about Ranexa (Ranolazine)?

You should not take ranolazine if you are allergic to it, or if you have:

  • cirrhosis of the liver.

Many drugs can interact and cause dangerous effects. Some drugs should not be used together with ranolazine. Your doctor may change your treatment plan if you also use:

  • clarithromycin;
  • nefazodone;
  • St. John's wort;
  • antifungal medicine–itraconazole, ketoconazole;
  • HIV or AIDS medicine–indinavir, lopinavir/ritonavir, nelfinavir, ritonavir, saquinavir;
  • seizure medicine–carbamazepine, phenobarbital, phenytoin; or
  • tuberculosis medicine–rifabutin, rifampin, rifapentine.

Tell your doctor if you have ever had:

  • long QT syndrome (in you or a family member);
  • liver disease; or
  • kidney disease.

Tell your doctor if you are pregnant or breastfeeding.

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Side Effects

What are the side effects of Ranexa (Ranolazine)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;
  • fast or pounding heartbeats, fluttering in your chest; or
  • kidney problems–little or no urination, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath.

Common side effects may include:

  • nausea, constipation;
  • headache; or
  • dizziness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Pregnancy & Breastfeeding

Can I take Ranexa (Ranolazine) if I’m pregnant or breastfeeding?

Tell your doctor if you are pregnant or breastfeeding.


What drugs and food should I avoid while taking Ranexa (Ranolazine)?

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Grapefruit may interact with ranolazine and lead to unwanted side effects. Avoid the use of grapefruit products.

Dosage Guidelines & Tips

How to take Ranexa (Ranolazine)?

Use Ranexa (Ranolazine) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

You may take ranolazine with or without food.

Swallow the tablet whole and do not crush, chew, or break it.

Chronic angina is often treated with a combination of drugs. Use all medications as directed and read all medication guides you receive. Do not change your dose or dosing schedule without your doctor's advice.

Call your doctor if your symptoms do not improve, or if they get worse.

You will need frequent medical tests to check your heart and kidney function.

Store at room temperature away from moisture and heat.

What should I do if I missed a dose of Ranexa (Ranolazine)?

Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.

Overdose Signs

What happens if I overdose on Ranexa (Ranolazine)?

Overdose can cause nausea, vomiting, numbness or tingling, dizziness, double vision, confusion, or fainting.

If you think you or someone else may have overdosed on: Ranexa (Ranolazine),  call your doctor or the Poison Control center

(800) 222-1222

If someone collapses or isn't breathing after taking Ranexa (Ranolazine), call 911




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