Pseudoephedrine And Triprolidine (Actifed) – Side Effects, Interactions, Uses, Dosage, Warnings

Pseudoephedrine and triprolidine is a combination antihistamine and decongestant medicine that is used to treat runny or stuffy nose, sneezing, itching, watery eyes, and sinus congestion caused by allergies or the common cold.

Pseudoephedrine and triprolidine may also be used for purposes not listed in this medication guide.


What is Pseudoephedrine And Triprolidine (Actifed) used for?

  • Allergic Rhinitis
  • Cold Symptoms


What is the most important information I should know about Pseudoephedrine And Triprolidine (Actifed)?

You should not use this medicine if you are allergic to pseudoephedrine or triprolidine.

Do not use pseudoephedrine and triprolidine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine, and others.

Ask a doctor or pharmacist if this medicine is safe to use if you have ever had:

  • asthma or other breathing disorder such as emphysema or chronic bronchitis;
  • high blood pressure, heart disease;
  • glaucoma;
  • diabetes; or
  • a thyroid disorder.

Ask a doctor before using this medicine if you are pregnant or breastfeeding.

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Side Effects

What are the side effects of Pseudoephedrine And Triprolidine (Actifed)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

  • severe dizziness;
  • nervousness;
  • trouble sleeping; or
  • high blood pressure (severe headache, pounding in your neck or ears).

Common side effects may include:

  • dizziness, drowsiness;
  • dry mouth, nose, or throat;
  • constipation;
  • blurred vision; or
  • feeling restless or excited (especially in children).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Pregnancy & Breastfeeding

Can I take Pseudoephedrine And Triprolidine (Actifed) if I’m pregnant or breastfeeding?

Ask a doctor before using this medicine if you are pregnant or breastfeeding.


What drugs and food should I avoid while taking Pseudoephedrine And Triprolidine (Actifed)?

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Ask a doctor or pharmacist before using other cough or cold medicines that may contain similar ingredients.

Drinking alcohol can increase certain side effects of triprolidine.

Dosage Guidelines & Tips

How to take Pseudoephedrine And Triprolidine (Actifed)?

Use Pseudoephedrine And Triprolidine (Actifed) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Use exactly as directed on the label, or as prescribed by your doctor. Cold or cough medicine is only for short-term use until your symptoms clear up.

Measure liquid medicine with the supplied syringe or a dose-measuring device (not a kitchen spoon).

Always follow directions on the medicine label about giving cough or cold medicine to a child. Do not use the medicine only to make a child sleepy. Death can occur from the misuse of cough or cold medicines in very young children.

Call your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.

If you need surgery or medical tests, tell the surgeon or doctor ahead of time if you have taken this medicine within the past few days.

Store at room temperature away from moisture and heat.

What should I do if I missed a dose of Pseudoephedrine And Triprolidine (Actifed)?

Since pseudoephedrine and triprolidine is used when needed, you may not be on a dosing schedule. Skip any missed dose if it's almost time for your next dose. Do not use two doses at one time.

Overdose Signs

What happens if I overdose on Pseudoephedrine And Triprolidine (Actifed)?

If you think you or someone else may have overdosed on: Pseudoephedrine And Triprolidine (Actifed),  call your doctor or the Poison Control center

(800) 222-1222

If someone collapses or isn't breathing after taking Pseudoephedrine And Triprolidine (Actifed), call 911



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