Propantheline (Pro-Banthine) – Side Effects, Interactions, Uses, Dosage, Warnings

Propantheline is used as part of a treatment for a peptic ulcer.

Propantheline may also be used for purposes not listed in this medication guide.


What is Propantheline (Pro-Banthine) used for?

  • Zollinger-Ellison Syndrome
  • Peptic Ulcer
  • Peptic Ulcer with Hemorrhage
  • Peptic Ulcer with Hemorrhage and Perforation
  • Peptic Ulcer with Perforation
  • Peptic Ulcer with Hemorrhage and Obstruction
  • Peptic Ulcer with Perforation and Obstruction
  • Peptic Ulcer with Hemorrhage/Perforation/Obstruction
  • Peptic Ulcer with Obstruction


What is the most important information I should know about Propantheline (Pro-Banthine)?

You should not take propantheline if you are allergic to it, or if you have:

  • a stomach or bowel obstruction (including paralytic ileus);
  • glaucoma;
  • a bladder obstruction or other urination problems;
  • severe constipation;
  • severe ulcerative colitis or toxic megacolon;
  • active bleeding with fast heartbeats, low blood pressure, shortness of breath, and cold hands or feet; or
  • myasthenia gravis.

Tell your doctor if you have ever had:

  • a nerve-muscle disorder;
  • heart disease, or a heart rhythm disorder;
  • high blood pressure;
  • an intestinal disorder such as ulcerative colitis;
  • liver or kidney disease;
  • hiatal hernia or reflux esophagitis (GERD);
  • a thyroid disorder; or
  • a colostomy or ileostomy.

Tell your doctor if you are pregnant or breast-feeding.

Older adults may be more sensitive to the effects of this medicine.

Propantheline is not approved for use by anyone younger than 18 years old.

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Side Effects

What are the side effects of Propantheline (Pro-Banthine)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using propantheline and call your doctor at once if you have:

  • diarrhea;
  • fast or pounding heartbeats, fluttering in your chest;
  • eye pain or redness, seeing halos around lights;
  • painful or difficult urination; or
  • little or no urination.

Common side effects may include:

  • dry mouth, nose, or throat;
  • blurred vision;
  • constipation;
  • headache, dizziness, drowsiness;
  • confusion or feeling nervous;
  • decreased sweating;
  • nausea, vomiting, bloating;
  • decreased sense of taste;
  • impotence, sexual problems; or
  • sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Pregnancy & Breastfeeding

Can I take Propantheline (Pro-Banthine) if I’m pregnant or breastfeeding?

Risk cannot be ruled out
Based on FDA pregnancy categories

Tell your doctor if you are pregnant or breast-feeding.


What drugs and food should I avoid while taking Propantheline (Pro-Banthine)?

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Propantheline can decrease perspiration and you may be more prone to heat stroke.

Dosage Guidelines & Tips

How to take Propantheline (Pro-Banthine)?

Use Propantheline (Pro-Banthine) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Propantheline is usually taken 3 or 4 times a day, 30 minutes before meals and at bedtime. Follow your doctor's instructions.

Store propantheline at room temperature away from moisture and heat.

What should I do if I missed a dose of Propantheline (Pro-Banthine)?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

Overdose Signs

What happens if I overdose on Propantheline (Pro-Banthine)?

Overdose symptoms may include feeling restless or excited, warmth or tingling under your skin, confusion, unusual thoughts or behavior, muscle weakness, or paralysis.

If you think you or someone else may have overdosed on: Propantheline (Pro-Banthine),  call your doctor or the Poison Control center

(800) 222-1222

If someone collapses or isn't breathing after taking Propantheline (Pro-Banthine), call 911



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