Probenecid is used to treat gout and gouty arthritis. This medicine reduces the amount of uric acid in your body by causing it to be passed in your urine.
Probenecid is also sometimes given together with penicillin antibiotics (including ampicillin, methicillin, oxacillin, cloxacillin, or nafcillin) to make them more effective.
Probenecid may also be used for purposes not listed in this medication guide.
uses
What is Probenecid (Benemid) used for?
- Adjunct to Antibiotic Therapy
- Gout
- Gouty Arthritis
- Uric Acid Nephrolithiasis
- Gouty Nephropathy
- Lesch-Nyhan Syndrome
warnings
What is the most important information I should know about Probenecid (Benemid)?
You should not use probenecid if you are allergic to it, or if you have:
- uric acid kidney stones;
- a gout attack that has already started; or
- a blood cell disorder, such as anemia or low white blood cells.
Probenecid should not be given to a child younger than 2 years old.
Tell your doctor if you have ever had:
- kidney disease;
- a stomach ulcer; or
- kidney stones.
Tell your doctor if you are pregnant or breast-feeding.
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Side Effects
What are the side effects of Probenecid (Benemid)?
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
- worsening gout symptoms;
- nausea, vomiting, stomach pain or swelling;
- painful or difficult urination;
- severe pain in your side or lower back;
- blood in your urine;
- urine that looks cloudy or foamy;
- puffy eyes, swelling in your ankles or feet, weight gain; or
- pale or yellowed skin.
Common side effects may include:
- headache, dizziness;
- nausea, vomiting, loss of appetite;
- flushing (sudden warmth, redness, or tingly feeling);
- sore gums;
- urinating more than usual;
- itching, rash; or
- hair loss.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Pregnancy & Breastfeeding
Can I take Probenecid (Benemid) if I’m pregnant or breastfeeding?
Tell your doctor if you are pregnant or breast-feeding.
Interactions
What drugs and food should I avoid while taking Probenecid (Benemid)?
Ask a doctor or pharmacist if you feel you need to take a mild pain reliever. Avoid using any medicine that may contain aspirin or other salicylates (such as Disalsid, Doan's Extra Strength, Ecotrin, Novasal, Nuprin Backache, Salflex, Salsitab, Tricosal, Trilisate, and others).
Dosage Guidelines & Tips
How to take Probenecid (Benemid)?
Use Probenecid (Benemid) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Drink plenty of water to prevent kidney stones while you are taking probenecid.
You may be given other medications to also help prevent kidney stones. Keep using these medicines for as long as your doctor has prescribed.
If you need surgery, tell your surgeon you currently take probenecid. This medicine may affect your body's response to anesthesia.
Call your doctor if your gout symptoms do not improve, or if they get worse. Your doctor may prescribe an additional medicine called colchicine.
Store at room temperature away from moisture, heat, and light.
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
Overdose Signs
What happens if I overdose on Probenecid (Benemid)?
Overdose symptoms may include nausea, vomiting, or stomach discomfort.
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