Darunavir is an antiviral medicine that is used to treat HIV (human immunodeficiency virus). HIV can cause acquired immunodeficiency syndrome (AIDS). Darunavir is not a cure for HIV or AIDS.
Darunavir must be given in combination with ritonavir and other antiviral medications and should not be used alone.
Darunavir may also be used for purposes not listed in this medication guide.
uses
What is Prezista (Darunavir) used for?
- HIV Infection
warnings
What is the most important information I should know about Prezista (Darunavir)?
You should not take darunavir if you have severe liver disease.
Some drugs should not be used with darunavir. Your treatment plan may change if you also use:
- alfuzosin;
- cisapride;
- colchicine (in people with liver or kidney disease);
- dronedarone;
- elbasvir and grazoprevir;
- lurasidone;
- naloxegol;
- pimozide;
- rifampin;
- sildenafil (Revatio, for pulmonary arterial hypertension);
- St. John's wort;
- triazolam or oral midazolam;
- heart medicine–ivabradine, ranolazine;
- cholesterol medication–lomitapide, lovastatin, simvastatin; or
- ergot medicines–dihydroergotamine, ergotamine, methylergonovine.
Tell your doctor if you have ever had:
- liver disease (especially hepatitis B or C);
- diabetes;
- a bleeding disorder such as hemophilia; or
- an allergy to sulfa drugs.
To prevent HIV in a newborn baby, use all medications to control your infection during pregnancy. Your name may be listed on an antiviral pregnancy registry.
Darunavir can make hormonal birth control less effective, including birth control pills, injections, implants, skin patches, and vaginal rings. To prevent pregnancy while using darunavir, use a barrier form of birth control: condom, diaphragm, cervical cap, or contraceptive sponge.
Women with HIV should not breastfeed. The virus can pass to your baby in your breast milk.
Darunavir and ritonavir should not be given to a child younger than 3 years old, or a child who weighs less than 22 pounds (10 kilograms).
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Side Effects
What are the side effects of Prezista (Darunavir)?
Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
Call your doctor at once if you have:
- a skin rash, no matter how mild;
- high blood sugar–increased thirst, increased urination, dry mouth, fruity breath odor; or
- signs of liver or pancreas problems–loss of appetite, upper stomach pain (that may spread to your back), nausea or vomiting, fast heart rate, dark urine, jaundice (yellowing of the skin or eyes).
Darunavir affects your immune system, which may cause certain side effects (even weeks or months after you've taken this medicine). Tell your doctor if you have:
- signs of a new infection–fever, night sweats, swollen glands, cold sores, cough, wheezing, diarrhea, weight loss;
- trouble speaking or swallowing, problems with balance or eye movement, weakness or prickly feeling; or
- swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence.
Common side effects may include:
- nausea, vomiting, diarrhea, stomach pain;
- headache;
- rash; or
- changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Pregnancy & Breastfeeding
Can I take Prezista (Darunavir) if I’m pregnant or breastfeeding?
To prevent HIV in a newborn baby, use all medications to control your infection during pregnancy. Your name may be listed on an antiviral pregnancy registry.
Darunavir can make hormonal birth control less effective, including birth control pills, injections, implants, skin patches, and vaginal rings. To prevent pregnancy while using darunavir, use a barrier form of birth control: condom, diaphragm, cervical cap, or contraceptive sponge.
Women with HIV should not breastfeed. The virus can pass to your baby in your breast milk.
Interactions
What drugs and food should I avoid while taking Prezista (Darunavir)?
Using this medicine will not prevent your disease from spreading. Do not have unprotected sex or share razors or toothbrushes. Ask your doctor how to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe.
Dosage Guidelines & Tips
How to take Prezista (Darunavir)?
Use Prezista (Darunavir) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Darunavir must be taken together with ritonavir and other antiviral medications. Use the medicine exactly as directed.
Doses are based on weight in children. Your child's dose may change if the child gains or loses weight.
Darunavir works best if you take it with food. Take darunavir and ritonavir together at the same time every day.
Swallow the darunavir tablet whole and do not crush, chew, or break it.
Shake the oral suspension (liquid). Measure a dose with the supplied syringe or a dose-measuring device (not a kitchen spoon).
You will need frequent medical tests.
Use all HIV medications as directed. Do not change your dose or stop using a medicine without your doctor's advice. Remain under the care of a doctor.
Store at room temperature away from moisture and heat.
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
Always take darunavir and ritonavir together.
Get your prescription refilled before you run out of medicine completely.
Overdose Signs
What happens if I overdose on Prezista (Darunavir)?
(800) 222-1222
911
Images
600MG, TMC
Color: orange
Shape: oval
Form: film coated
Imprint: 600MG, TMC
150, TMC
Color: white
Shape: oval
Form: film coated
Imprint: 150, TMC
800, T
Color: red
Shape: oval
Form: film coated
Imprint: 800, T