Estrogen is a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body. Conjugated estrogens are a mixture of estrogen hormones.
Conjugated estrogens are used in the vagina to treat the vaginal symptoms of menopause such as dryness, burning, irritation, and painful sexual intercourse.
Conjugated estrogens may also be used for purposes not listed in this medication guide.
uses
What is Premarin Vaginal (Conjugated Estrogens Vaginal) used for?
- Atrophic Vaginitis
- Postmenopausal Symptoms
warnings
What is the most important information I should know about Premarin Vaginal (Conjugated Estrogens Vaginal)?
You should not use conjugated estrogens if you have:
- unusual vaginal bleeding that has not been checked by a doctor;
- liver disease;
- a history of heart attack, stroke, or blood clot;
- an increased risk of having blood clots due to a heart problem or a hereditary blood disorder; or
- a history of hormone-related cancer, or cancer of the breast, uterus/cervix, or vagina.
Do not use conjugated estrogens if you are pregnant. Use effective birth control if you are not past menopause. Tell your doctor if you think you may be pregnant.
Conjugated estrogens vaginal cream can weaken the latex of a condom, diaphragm, or cervical cap. Talk to your doctor about the best birth control methods to use.
Using conjugated estrogens can increase your risk of blood clots, stroke, or heart attack. You are even more at risk if you have high blood pressure, diabetes, high cholesterol, if you are overweight, or if you smoke.
Estrogen should not be used to prevent heart disease, stroke, or dementia, because this medicine may actually increase your risk of developing these conditions.
Tell your doctor if you have ever had:
- a hysterectomy;
- heart disease;
- liver problems, or jaundice caused by pregnancy or taking hormones;
- kidney disease;
- gallbladder disease;
- asthma;
- epilepsy or other seizure disorder;
- migraines;
- lupus;
- endometriosis or uterine fibroid tumors;
- hereditary angioedema;
- porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system);
- a thyroid disorder; or
- high levels of calcium in your blood.
Using conjugated estrogens may increase your risk of cancer of the breast, uterus, or ovaries. Talk with your doctor about this risk.
Estrogen lowers the hormone needed to produce breast milk and can slow breast milk production. Tell your doctor if you are breast-feeding.
This medicine is not approved for use by anyone younger than 18 years old.
User Reviews & Rating
No ratings yet for Premarin Vaginal (Conjugated Estrogens Vaginal)
Leave a Review
Side Effects
What are the side effects of Premarin Vaginal (Conjugated Estrogens Vaginal)?
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
- heart attack symptoms–chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
- signs of a stroke–sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;
- signs of a blood clot–sudden vision loss, stabbing chest pain, feeling short of breath, coughing up blood, pain or warmth in one or both legs;
- swelling or tenderness in your stomach;
- jaundice (yellowing of the skin or eyes);
- memory problems, confusion, unusual behavior;
- unusual vaginal bleeding, pelvic pain;
- a lump in your breast; or
- high levels of calcium in your blood–nausea, vomiting, constipation, increased thirst or urination, muscle weakness, bone pain, lack of energy.
Common side effects may include:
- headache;
- pelvic pain;
- flushing (warmth, redness, or tingly feeling);
- breast pain; or
- vaginal itching or discharge, changes in your menstrual periods, breakthrough bleeding.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Pregnancy & Breastfeeding
Can I take Premarin Vaginal (Conjugated Estrogens Vaginal) if I’m pregnant or breastfeeding?
Do not use conjugated estrogens if you are pregnant. Use effective birth control if you are not past menopause. Tell your doctor if you think you may be pregnant.
Conjugated estrogens vaginal cream can weaken the latex of a condom, diaphragm, or cervical cap. Talk to your doctor about the best birth control methods to use.
Interactions
What drugs and food should I avoid while taking Premarin Vaginal (Conjugated Estrogens Vaginal)?
Avoid smoking. It can greatly increase your risk of blood clots, stroke, or heart attack while using conjugated estrogens.
Grapefruit may interact with conjugated estrogens and lead to unwanted side effects. Avoid the use of grapefruit products.
Dosage Guidelines & Tips
How to take Premarin Vaginal (Conjugated Estrogens Vaginal)?
Use Premarin Vaginal (Conjugated Estrogens Vaginal) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Conjugated estrogens may increase your risk of developing a condition that may lead to uterine cancer. Your doctor may prescribe a progestin to take while you are using conjugated estrogens, to help lower this risk. Report any unusual vaginal bleeding right away.
Conjugated estrogens are sometimes used on a daily basis. For certain conditions, the medicine is used in a cycle, such as 3 weeks on followed by 1 week off. Follow your doctor's instructions.
To apply this medication, use only the vaginal applicator provided. After each use, take the applicator apart and clean it with mild soap and warm water. Do not use hot or boiling water.
Your doctor should check your progress on a regular basis to determine whether you should continue this treatment. Self-examine your breasts for lumps on a monthly basis, and have regular mammograms.
If you need major surgery or will be on long-term bed rest, you may need to stop using this medicine for a short time. Any doctor or surgeon who treats you should know that you are using vaginal conjugated estrogens.
Store at room temperature away from moisture and heat.
Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.
Overdose Signs
What happens if I overdose on Premarin Vaginal (Conjugated Estrogens Vaginal)?
(800) 222-1222
911