Prednisolone (Orapred) – Side Effects, Interactions, Uses, Dosage, Warnings

Prednisolone is a steroid that prevents the release of substances in the body that cause inflammation.

Prednisolone is used to treat many different inflammatory conditions such as arthritis, lupus, psoriasis, ulcerative colitis, allergic disorders, gland (endocrine) disorders, and conditions that affect the skin, eyes, lungs, stomach, nervous system, or blood cells.

Prednisolone may also be used for purposes not listed in this medication guide.


What is Prednisolone (Orapred) used for?

  • Allergic Reaction
  • Ankylosing Spondylitis
  • Aspiration Pneumonia
  • Asthma — Acute
  • Asthma — Maintenance
  • Bursitis
  • Dermatitis Herpetiformis
  • Hypercalcemia of Malignancy
  • Idiopathic (Immune) Thrombocytopenic Purpura
  • Loeffler's Syndrome
  • Multiple Sclerosis
  • Nephrotic Syndrome
  • Osteoarthritis
  • Polymyositis/Dermatomyositis
  • Psoriasis
  • Rheumatoid Arthritis
  • Sarcoidosis
  • Seborrheic Dermatitis
  • Systemic Lupus Erythematosus
  • Ulcerative Colitis — Active
  • Uveitis
  • Anemia
  • Iritis
  • Optic Neuritis
  • Gouty Arthritis
  • Hemolytic Anemia
  • Anti-inflammatory
  • G-6-PD Deficiency
  • Immunosuppression
  • Neoplastic Diseases
  • Rheumatic Heart Disease
  • Collagen Vascular Disease
  • Adrenocortical Insufficiency
  • Thalassemia
  • Corneal Ulcers
  • Keratitis
  • Visual Defect/Disturbance
  • Sickle Cell Anemia
  • Thrombotic Thrombocytopenic Purpura
  • Infectious Posterior Uveitis
  • Hemoglobinopathy
  • Hemolytic Uremic Syndrome
  • Herpes Simplex Iridocyclitis
  • Herpes Zoster Iridocyclitis
  • Autoimmune Disorder
  • Autoimmune Hemolytic Anemia
  • Infectious Anterior Uveitis
  • Bone Marrow Depression/Low Blood Counts
  • Pemphigus
  • Felty's Syndrome
  • Psoriatic Arthropathy
  • Rheumatoid Lung
  • Syphilitic Uveitis
  • Uveitis (Anterior)
  • Panuveitis
  • Uveitis (Posterior)
  • Mycosis Fungoides
  • Juvenile Rheumatoid Arthritis
  • Psoriatic Arthritis
  • Epicondylitis
  • Iridocyclitis
  • Chorioretinitis
  • Choroiditis
  • Berylliosis
  • Synovitis
  • Thrombocythemia
  • Stevens-Johnson Syndrome
  • Serum Sickness
  • Erythema Multiforme


What is the most important information I should know about Prednisolone (Orapred)?

You should not use prednisolone if you are allergic to it, or if you have:

  • a fungal infection anywhere in your body.

Prednisolone can weaken your immune system, making it easier for you to get an infection. Steroids can also worsen an infection you already have, or reactivate an infection you recently had. Tell your doctor about any illness or infection you have had within the past several weeks.

To make sure prednisolone is safe for you, tell your doctor if you have ever had:

  • active tuberculosis;
  • a thyroid disorder;
  • herpes infection of the eyes;
  • stomach ulcers, ulcerative colitis, or diverticulitis;
  • depression, mental illness, or psychosis;
  • liver disease (especially cirrhosis);
  • high blood pressure;
  • osteoporosis;
  • a muscle disorder such as myasthenia gravis; or
  • multiple sclerosis.

Also tell your doctor if you have diabetes. Steroid medicines may increase the glucose (sugar) levels in your blood or urine. You may also need to adjust the dose of your diabetes medications.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether prednisolone passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.

User Reviews & Rating

Overall rating for Prednisolone (Orapred)

out of  5

(7 Prednisolone (Orapred) Reviews)

Side Effects


Easy to Use




Read Prednisolone (Orapred) Reviews

Side Effects

What are the side effects of Prednisolone (Orapred)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • shortness of breath (even with mild exertion), swelling, rapid weight gain;
  • bruising, thinning skin, or any wound that will not heal;
  • severe depression, changes in personality, unusual thoughts or behavior;
  • new or unusual pain in an arm or leg or in your back;
  • bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
  • severe pain in your upper stomach spreading to your back, nausea and vomiting;
  • a seizure (convulsions); or
  • low potassium–leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling.

Steroids can affect growth in children. Tell your doctor if your child is not growing at a normal rate while using this medicine.

Common side effects may include:

  • fluid retention (swelling in your hands or ankles);
  • dizziness, spinning sensation;
  • changes in your menstrual periods;
  • headache;
  • muscle pain or weakness; or
  • stomach discomfort, bloating.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Pregnancy & Breastfeeding

Can I take Prednisolone (Orapred) if I’m pregnant or breastfeeding?

Risk cannot be ruled out
Based on FDA pregnancy categories

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether prednisolone passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.


What drugs and food should I avoid while taking Prednisolone (Orapred)?

Do not receive a "live" vaccine while using prednisolone. The vaccine may not work as well during this time, and may not fully protect you from disease. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

Do not receive a smallpox vaccine or you could develop serious complications.

Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chickenpox or measles. These conditions can be serious or even fatal in people who are using steroid medication.

Dosage Guidelines & Tips

How to take Prednisolone (Orapred)?

Use Prednisolone (Orapred) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Prednisolone is sometimes taken every other day. Follow your doctor's dosing instructions very carefully.

Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

You may need to shake the oral suspension (liquid) well just before you measure a dose. Follow the directions on your medicine label.

Keep the disintegrating tablet in its blister pack until you are ready to take the medicine. Open the package using dry hands, and peel back the foil from the tablet blister (do not push the tablet through the foil). Remove the tablet and place it in your mouth.

Allow the disintegrating tablet to dissolve in your mouth without chewing. Swallow several times as the tablet dissolves. If desired, you may drink liquid to help swallow the dissolved tablet.

Your dose needs may change if you have unusual stress such as a serious illness, fever or infection, or if you have surgery or a medical emergency. Tell your doctor about any such situation that affects you.

This medicine can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using prednisolone.

You should not stop using prednisolone suddenly. Follow your doctor's instructions about tapering your dose.

Wear a medical alert tag or carry an ID card stating that you take prednisolone. Any medical care provider who treats you should know that you take steroid medication.

If you need surgery, tell the surgeon ahead of time that you are using prednisolone. You may need to stop using the medicine for a short time.

Store at room temperature away from moisture and heat.

What should I do if I missed a dose of Prednisolone (Orapred)?

Call your doctor for instructions if you miss a dose of prednisolone.

Overdose Signs

What happens if I overdose on Prednisolone (Orapred)?

An overdose of prednisolone is not expected to produce life threatening symptoms. However, long term use of high steroid doses can lead to symptoms such as thinning skin, easy bruising, changes in the shape or location of body fat (especially in your face, neck, back, and waist), increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex.

If you think you or someone else may have overdosed on: Prednisolone (Orapred),  call your doctor or the Poison Control center

(800) 222-1222

If someone collapses or isn't breathing after taking Prednisolone (Orapred), call 911



DAN DAN, 5059

Color: orange

Shape: round

Imprint: DAN DAN, 5059

5059, DAN DAN

Color: orange

Shape: round

Imprint: 5059, DAN DAN

No image available


Color: peach

Shape: round

Imprint: DANDAN5059

See More

Leave a comment

Your email address will not be published. Required fields are marked *