Pralidoxime (Protopam Chloride) – Side Effects, Interactions, Uses, Dosage, Warnings

Pralidoxime is used as an antidote to treat poisoning caused by chemicals, pesticides (insect sprays), or drugs used to treat a muscle disorder.

This medication is not effective as an antidote for all types of pesticide poisonings.

Pralidoxime may also be used for purposes not listed in this medication guide.


What is Pralidoxime (Protopam Chloride) used for?

  • Anticholinesterase Overdose
  • Organophosphate Poisoning
  • Nerve Agent Poisoning


What is the most important information I should know about Pralidoxime (Protopam Chloride)?

If possible during an emergency, tell your caregivers if you've ever had:

  • an allergy to any medication;
  • liver or kidney disease;
  • heart problems; or
  • high blood pressure.

If possible during an emergency, tell your caregivers if you are pregnant or breastfeeding.

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Side Effects

What are the side effects of Pralidoxime (Protopam Chloride)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some of the side effects of pralidoxime may be similar to the symptoms of poisoning. Your caregivers will watch you closely to determine whether your body is responding well to the medication, or if you are having any serious side effects.

Tell your caregivers right away if you have:

  • fast or pounding heartbeats;
  • chest tightness, shortness of breath;
  • anxiety, dizziness, or nervousness;
  • numbness or tingling;
  • painful or difficult urination;
  • little or no urination;
  • vision problems; or
  • muscular weakness.

Side effects may be more likely in older adults.

Common side effects may include:

  • pain for up to an hour after injection into a muscle;
  • trouble breathing;
  • vision changes;
  • nausea;
  • fast heartbeats, increased blood pressure;
  • headache, dizziness, drowsiness; or
  • muscle weakness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Pregnancy & Breastfeeding

Can I take Pralidoxime (Protopam Chloride) if I’m pregnant or breastfeeding?

If possible during an emergency, tell your caregivers if you are pregnant or breastfeeding.


What drugs and food should I avoid while taking Pralidoxime (Protopam Chloride)?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Dosage Guidelines & Tips

How to take Pralidoxime (Protopam Chloride)?

Use Pralidoxime (Protopam Chloride) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Pralidoxime is injected into a muscle, under the skin, or into a vein.

Your breathing, blood pressure, oxygen levels, kidney function, and other vital signs will be watched closely.

You may be watched for up to 72 hours to make sure the medicine has been effective and you no longer have any effects of the poison.

What should I do if I missed a dose of Pralidoxime (Protopam Chloride)?

In a medical setting you are not likely to miss a dose.

Overdose Signs

What happens if I overdose on Pralidoxime (Protopam Chloride)?

In a medical setting an overdose would be treated quickly.

If you think you or someone else may have overdosed on: Pralidoxime (Protopam Chloride),  call your doctor or the Poison Control center

(800) 222-1222

If someone collapses or isn't breathing after taking Pralidoxime (Protopam Chloride), call 911


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