Polivy (Polatuzumab Vedotin) – Side Effects, Interactions, Uses, Dosage, Warnings

Polatuzumab vedotin is used to treat diffuse large B-cell lymphoma after at least two other cancer treatments did not work or have stopped working.

Polatuzumab vedotin is given in combination with bendamustine (Bendeka, Treanda) and a medicine that contains rituximab (Rituxan).

Polatuzumab vedotin may also be used for purposes not listed in this medication guide.


What is Polivy (Polatuzumab Vedotin) used for?

  • Lymphoma


What is the most important information I should know about Polivy (Polatuzumab Vedotin)?

Tell your doctor if you have ever had:

  • liver disease; or
  • nerve problems (neuropathy) in your hands and feet.

Polatuzumab vedotin can harm an unborn baby or cause birth defects if the mother or the father is using this medicine.

  • If you are a woman, you may need to have a negative pregnancy test before starting this treatment. Do not use polatuzumab vedotin if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 3 months after your last dose.
  • If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 5 months after your last dose.
  • Tell your doctor right away if a pregnancy occurs while either the mother or the father is using polatuzumab vedotin.

This medicine may affect fertility (ability to have children) in men. However, it is important to use birth control to prevent pregnancy because polatuzumab vedotin can harm an unborn baby.

Do not breastfeed while using this medicine, and for at least 2 months after your last dose.

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Side Effects

What are the side effects of Polivy (Polatuzumab Vedotin)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Polatuzumab vedotin may cause a serious brain infection that can lead to disability or death. Call your doctor right away if you have problems with speech, thought, vision, or muscle movement. These symptoms may start gradually and get worse quickly.

Some side effects may occur during the injection. Tell your caregiver if you feel feverish, chilled, itchy, light-headed, or have wheezing, chest tightness, or trouble breathing within 24 hours after the injection.

Call your doctor at once if you have:

  • easy bruising or bleeding (nosebleeds, bleeding gums);
  • muscle weakness;
  • cough with mucus, chest pain, feeling short of breath;
  • pale skin, cold hands and feet, feeling light-headed;
  • nerve problems–numbness, tingling, pain, burning sensation in your hands or feet, weakness, trouble walking;
  • signs of infection–fever, chills, night sweats, cough, mouth sores, swollen glands, shallow breathing, pain or burning when you urinate, weight loss;
  • signs of shingles–flu-like symptoms, tingly or painful blistering rash on one side of your body;
  • liver problems–loss of appetite, stomach pain (upper right side), dark urine, jaundice (yellowing of the skin or eyes); or
  • signs of tumor cell breakdown–confusion, weakness, muscle cramps, nausea, vomiting, fast or slow heart rate, decreased urination, tingling in your hands and feet or around your mouth.

Common side effects may include:

  • fever, cough, tiredness, or other signs of infection;
  • nerve problems; or
  • diarrhea, loss of appetite.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Pregnancy & Breastfeeding

Can I take Polivy (Polatuzumab Vedotin) if I’m pregnant or breastfeeding?

Do not breastfeed while using this medicine, and for at least 2 months after your last dose.


What drugs and food should I avoid while taking Polivy (Polatuzumab Vedotin)?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Dosage Guidelines & Tips

How to take Polivy (Polatuzumab Vedotin)?

Use Polivy (Polatuzumab Vedotin) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Polatuzumab vedotin is given as an infusion into a vein. A healthcare provider will give you this injection.

Polatuzumab vedotin is usually given once every 21 days, along with bendamustine and rituximab. Your doctor will determine how long to treat you with these medicines.

You may be given other medications to help prevent serious side effects, allergic reaction, or infections. Keep using these medicines for as long as your doctor has prescribed.

Polatuzumab vedotin affects your immune system. You may get infections more easily, even serious or fatal infections. Your blood will need to be tested often, and further doses may be delayed based on the results.

What should I do if I missed a dose of Polivy (Polatuzumab Vedotin)?

Call your doctor for instructions if you miss an appointment for your polatuzumab vedotin injection.

Overdose Signs

What happens if I overdose on Polivy (Polatuzumab Vedotin)?

Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

If you think you or someone else may have overdosed on: Polivy (Polatuzumab Vedotin),  call your doctor or the Poison Control center

(800) 222-1222

If someone collapses or isn't breathing after taking Polivy (Polatuzumab Vedotin), call 911


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