Promethazine is used to treat allergy symptoms such as itching, runny nose, sneezing, itchy or watery eyes, hives, and itchy skin rashes.
Promethazine also prevents motion sickness, and treats nausea and vomiting or pain after surgery. It is also used as a sedative or sleep aid.
Promethazine is not for use in treating symptoms of asthma, pneumonia, or other lower respiratory tract infections.
Promethazine may also be used for purposes not listed in this medication guide.
What is Phenergan (Promethazine Injection) used for?
- Allergic Reaction
- Allergic Rhinitis
- Light Sedation
- Motion Sickness
- Opiate Adjunct
- Allergic Urticaria
- Physical Urticaria
What is the most important information I should know about Phenergan (Promethazine Injection)?
Promethazine should not be given to a child younger than 2 years old. Promethazine can cause severe breathing problems or death in very young children. Carefully follow your doctor's instructions when giving this medicine to a child of any age.
You should not take this medicine if you are allergic to promethazine or to similar medicines such as chlorpromazine, fluphenazine, mesoridazine, perphenazine, prochlorperazine, thioridazine, or trifluoperazine.
Tell your doctor if you have ever had:
- asthma, chronic obstructive pulmonary disease (COPD), sleep apnea, or other breathing disorder;
- a history of seizures;
- a weak immune system (bone marrow depression);
- enlarged prostate or problems with urination;
- stomach ulcer or obstruction;
- heart disease or high blood pressure;
- liver disease; or
- if you have ever had a serious side effect while using promethazine or any other phenothiazine.
Tell your doctor if you are pregnant or breastfeeding.
What are the side effects of Phenergan (Promethazine Injection)?
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
- severe drowsiness, weak or shallow breathing;
- a light-headed feeling, like you might pass out;
- confusion, agitation, hallucinations, nightmares;
- seizure (convulsions);
- fast or slow heartbeats;
- jaundice (yellowing of the skin or eyes);
- uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);
- easy bruising or bleeding (nosebleeds, bleeding gums);
- sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, red or swollen gums, trouble swallowing; or
- severe nervous system reaction–very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.
Common side effects may include:
- drowsiness, dizziness;
- ringing in your ears;
- double vision;
- feeling nervous;
- dry mouth; or
- tiredness, sleep problems (insomnia).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Pregnancy & Breastfeeding
Can I take Phenergan (Promethazine Injection) if I’m pregnant or breastfeeding?
Tell your doctor if you are pregnant or breastfeeding.
What drugs and food should I avoid while taking Phenergan (Promethazine Injection)?
This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
Drinking alcohol can increase certain side effects of promethazine.
Avoid exposure to sunlight or tanning beds. Promethazine can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
Dosage Guidelines & Tips
How to take Phenergan (Promethazine Injection)?
Use Phenergan (Promethazine Injection) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Promethazine is often taken at bedtime or before meals. For motion sickness, promethazine is usually started within 1 hour before traveling. When used for surgery, promethazine is usually taken the night before the surgery.
How often you take this medicine and the timing of your dose will depend on the condition being treated.
Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.
If a child is using this medicine, tell your doctor if the child has any changes in weight. Promethazine doses are based on weight in children, and any changes may affect your child's dose.
Call your doctor if your symptoms do not improve, or if they get worse while using promethazine.
This medicine can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using promethazine.
Store at room temperature away from moisture, heat, and light.
What happens if I overdose on Phenergan (Promethazine Injection)?
Overdose symptoms may include overactive reflexes, loss of coordination, severe drowsiness or weakness, fainting, dilated pupils, weak or shallow breathing, or seizure (convulsions).
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