Pexidartinib (Turalio) – Side Effects, Interactions, Uses, Dosage, Warnings

Pexidartinib is used to treat giant cell tumor of the tendon sheath (also called tenosynovial giant cell tumor, or pigmented villonodular synovitis).

Pexidartinib is available only under a special program. You must be registered in the program and understand the risks and benefits of this medicine.

Pexidartinib may also be used for purposes not listed in this medication guide.


What is Pexidartinib (Turalio) used for?

  • Giant Cell Tumor of Bone


What is the most important information I should know about Pexidartinib (Turalio)?

Tell your doctor if you have ever had:

  • liver disease; or
  • kidney disease.

Pexidartinib can harm an unborn baby if the mother or the father is using this medicine.

  • If you are a woman, you may need to have a negative pregnancy test before starting this treatment. Do not use pexidartinib if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 1 month after your last dose.
  • If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 1 week after your last dose.
  • Tell your doctor right away if a pregnancy occurs while either the mother or the father is using pexidartinib.

This medicine may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because pexidartinib can harm an unborn baby.

Do not breastfeed while using this medicine, and for at least 1 week after your last dose.

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Side Effects

What are the side effects of Pexidartinib (Turalio)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using pexidartinib and call your doctor at once if you have dark urine or jaundice (yellowing of the skin or eyes).

Tell your doctor if you have other symptoms of liver problems, such as:

  • right-sided upper stomach pain;
  • loss of appetite, nausea, vomiting;
  • fever, tiredness; or
  • itching.

Your pexidartinib doses may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

  • abnormal liver function tests;
  • high cholesterol;
  • low blood cell counts;
  • puffy eyes;
  • changes in the color of your hair;
  • rash; or
  • decreased or altered sense of taste.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Pregnancy & Breastfeeding

Can I take Pexidartinib (Turalio) if I’m pregnant or breastfeeding?

Do not breastfeed while using this medicine, and for at least 1 week after your last dose.


What drugs and food should I avoid while taking Pexidartinib (Turalio)?

Grapefruit may interact with pexidartinib and lead to unwanted side effects. Avoid the use of grapefruit products.

Dosage Guidelines & Tips

How to take Pexidartinib (Turalio)?

Use Pexidartinib (Turalio) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

You must remain under the care of a doctor while taking pexidartinib.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Take pexidartinib on an empty stomach, at least 1 hour before or 2 hours after a meal.

Swallow the capsule whole and do not crush, chew, break, or open it.

If you vomit shortly after taking pexidartinib, do not take another dose. Wait until your next scheduled dose time to take the medicine again.

You will need blood tests to check your liver function before you start taking pexidartinib and every 1 to 3 weeks for the first 2 months. After that your liver function will be checked at least every 3 months as you continue taking this medicine.

Your next dose may be delayed based on the results of your liver function tests.

Store at room temperature away from moisture and heat. Keep the tablets in their original container, along with the packet or canister of moisture-absorbing preservative.

What should I do if I missed a dose of Pexidartinib (Turalio)?

Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.

Overdose Signs

What happens if I overdose on Pexidartinib (Turalio)?

If you think you or someone else may have overdosed on: Pexidartinib (Turalio),  call your doctor or the Poison Control center

(800) 222-1222

If someone collapses or isn't breathing after taking Pexidartinib (Turalio), call 911



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