Osilodrostat is used in adults to treat Cushing's disease that cannot be treated with pituitary surgery.
Osilodrostat may also be used for purposes not listed in this medication guide.
uses
What is Osilodrostat (Isturisa) used for?
- Cushing's Syndrome
warnings
What is the most important information I should know about Osilodrostat (Isturisa)?
Tell your doctor if you have ever had:
- a heart rhythm disorder;
- long QT syndrome (in you or a family member);
- congestive heart failure;
- high blood pressure;
- an electrolyte imbalance (such as low levels of potassium or magnesium in your blood);
- fluid retention; or
- liver disease.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether osilodrostat will harm an unborn baby. However, having Cushing's disease during pregnancy may cause complications such as diabetes or eclampsia (dangerously high blood pressure that can lead to medical problems in both mother and baby). The benefit of treating Cushing's disease may outweigh any risks to the baby.
Do not breastfeed while using this medicine, and for at least 1 week after your last dose.
Osilodrostat is not approved for use by anyone younger than 18 years old.
User Reviews & Rating
No ratings yet for Osilodrostat (Isturisa)
Leave a Review
Side Effects
What are the side effects of Osilodrostat (Isturisa)?
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
- fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out);
- swelling in your feet or ankles, feeling short of breath;
- decreased adrenal gland hormones–nausea, vomiting, stomach pain, loss of appetite, feeling tired or light-headed, muscle or joint pain, skin discoloration, craving salty foods;
- increased adrenal gland hormones–hunger, weight gain, swelling, skin discoloration, slow wound healing, sweating, acne, increased body hair, tiredness, mood changes, muscle weakness, missed menstrual periods, sexual changes; or
- low potassium level–leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling.
Common side effects may include:
- nausea;
- feeling tired;
- headache; or
- swelling.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Pregnancy & Breastfeeding
Can I take Osilodrostat (Isturisa) if I’m pregnant or breastfeeding?
Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether osilodrostat will harm an unborn baby. However, having Cushing's disease during pregnancy may cause complications such as diabetes or eclampsia (dangerously high blood pressure that can lead to medical problems in both mother and baby). The benefit of treating Cushing's disease may outweigh any risks to the baby.
Do not breastfeed while using this medicine, and for at least 1 week after your last dose.
Interactions
What drugs and food should I avoid while taking Osilodrostat (Isturisa)?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Dosage Guidelines & Tips
How to take Osilodrostat (Isturisa)?
Use Osilodrostat (Isturisa) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
You may take osilodrostat with or without food.
Your doctor will check your heart function using an electrocardiograph or ECG (sometimes called an EKG). Your next dose may be delayed based on the results of your ECG or other medical tests.
Do not change your dose or dosing schedule without your doctor's advice.
Store at room temperature away from moisture and heat.
Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.
Overdose Signs
What happens if I overdose on Osilodrostat (Isturisa)?
Overdose symptoms may include nausea, vomiting, stomach pain, extreme tiredness, feeling light-headed, or fainting.
(800) 222-1222
911
Images
Y3, NVR
Color: brown
Shape: round
Imprint: Y3, NVR
Y1, NVR
Color: yellow
Shape: round
Imprint: Y1, NVR
Y2, NVR
Color: yellow
Shape: round
Imprint: Y2, NVR