Nifurtimox (Lampit) – Side Effects, Interactions, Uses, Dosage, Warnings

Nifurtimox is used to treat Chagas disease, a condition caused by a parasite. Chagas disease occurs most commonly in Mexico, Central America, and South America.

Nifurtimox is for use in children from birth through their 17th year. A child must weigh at least 5.5 pounds (2.5 kilograms) before taking this medicine.

Nifurtimox may also be used for purposes not listed in this medication guide.

uses

What is Nifurtimox (Lampit) used for?

  • Trypanosomiasis

warnings

What is the most important information I should know about Nifurtimox (Lampit)?

Nifurtimox should not be used if the child is allergic to it.

Tell your child's doctor if the child has ever had:

  • a brain injury;
  • a seizure;
  • mental illness or psychosis;
  • kidney disease (or if the child is on dialysis);
  • liver disease; or
  • porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system).

Nifurtimox can harm an unborn baby if the mother or the father is using this medicine.

  • If you are a woman, you may need a pregnancy test to make sure you are not pregnant. Use birth control while using this medicine and for at least 6 months after your last dose.
  • If you are a man, use birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.
  • Tell the doctor right away if a pregnancy occurs.

It may be harder for you to get a woman pregnant while you are using this medicine.

If you are breastfeeding, tell the doctor if you notice symptoms in the nursing baby such as fussiness, decreased appetite, vomiting, rash, or fever.

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Side Effects

What are the side effects of Nifurtimox (Lampit)?

Get emergency medical help if the child has signs of an allergic reaction: hives, itching; feeling light-headed; difficult breathing; swelling of the face, lips, tongue, or throat.

Call your child's doctor at once if the child has:

  • a decreased appetite and weight loss;
  • new or worsening symptoms of a pre-existing condition (such as a brain injury, seizures, behavior changes, or mental health problems); or
  • worsening symptoms of porphyria (dark urine, severe stomach pain, muscle pain, numbness, tingling, mental changes, or skin sensitivity to light).

Common side effects may include:

  • stomach pain, nausea, vomiting;
  • loss of appetite;
  • fever;
  • rash; or
  • headache.

This is not a complete list of side effects and others may occur. Call your child's doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Pregnancy & Breastfeeding

Can I take Nifurtimox (Lampit) if I’m pregnant or breastfeeding?

If you are breastfeeding, tell the doctor if you notice symptoms in the nursing baby such as fussiness, decreased appetite, vomiting, rash, or fever.

Interactions

What drugs and food should I avoid while taking Nifurtimox (Lampit)?

Follow your child's doctor's instructions about any restrictions on food, beverages, or activity.

This medicine may cause muscle weakness or tremors and may impair your child's reactions. Your child should avoid driving or hazardous activity until you know the effects of this medicine.

Dosage Guidelines & Tips

How to take Nifurtimox (Lampit)?

Use Nifurtimox (Lampit) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your child's dose. Take the medicine exactly as directed.

The usual dosage of nifurtimox is 3 times per day with food, taken for 60 days. Follow the doctor's dosing instructions very carefully.

Each tablet should be swallowed whole or split in half. You may split a tablet by breaking it along scored line with your fingertip. Do not split a nifurtimox tablet using a tablet-cutting device.

If the child cannot swallow a tablet whole, place the tablet into 1/2 teaspoon of water. Allow the tablet to completely dissolve (in about 30 seconds). Give the mixture right away with food.

Nifurtimox doses are based on weight and may change if the child gains or loses weight. The doctor should check the child's weight every 2 weeks while the child takes nifurtimox.

Store at room temperature away from moisture and heat.

Keep the tablets in their original container, along with the packet or canister of moisture-absorbing preservative.

What should I do if I missed a dose of Nifurtimox (Lampit)?

Give the medicine as soon as you can, but skip the missed dose if your child's next dose is due in less than 3 hours. Do not take two doses at one time.

Overdose Signs

What happens if I overdose on Nifurtimox (Lampit)?

If you think you or someone else may have overdosed on: Nifurtimox (Lampit),  call your doctor or the Poison Control center

(800) 222-1222

If someone collapses or isn't breathing after taking Nifurtimox (Lampit), call 911

911

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