Dihydroergotamine nasal is used to treat migraine headaches with or without aura in adults. Dihydroergotamine nasal will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks.
Dihydroergotamine nasal should not be used to treat common tension headaches or any headache that seems to be different from your usual migraine headaches.
Dihydroergotamine nasal may also be used for purposes not listed in this medication guide.
uses
What is Migranal (Dihydroergotamine Injection) used for?
- Cluster Headache
- Migraine
warnings
What is the most important information I should know about Migranal (Dihydroergotamine Injection)?
You should not use dihydroergotamine if you are allergic to it or similar medicines (ergotamine, ergonovine, methylergonovine, and others), or if you have:
- heart disease, angina (chest pain), blood circulation problems, coronary artery disease (hardening of the arteries), or history of a heart attack or stroke;
- uncontrolled high blood pressure;
- severe liver or kidney disease;
- a serious infection called sepsis; or
- if you have had vascular surgery.
Some drugs should not be used with dihydroergotamine. Your treatment plan may change if you also use:
- an antibiotic such as clarithromycin or erythromycin;
- antifungal medicine such as itraconazole or ketoconazole; or
- antiviral medicine for HIV or hepatitis C.
Tell your doctor if you have ever had:
- blood circulation problems in your arms, hands, legs, or feet;
- chest pain, shortness of breath;
- liver or kidney disease; or
- risk factors for coronary artery disease (high blood pressure, high cholesterol, diabetes, menopause, smoking, family history of coronary artery disease, being overweight, being over 40 and a man).
Dihydroergotamine can affect blood circulation to your uterus. Tell your doctor if you are pregnant or plan to become pregnant. Do not use this medicine if you are pregnant.
Do not breastfeed while using this medicine, and for at least 3 days after your last dose. Talk with your doctor about the best way to feed your baby.
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Side Effects
What are the side effects of Migranal (Dihydroergotamine Injection)?
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
- signs of a blood clot–sudden numbness or weakness on one side of the body, problems with vision or speech, pain or swelling in one leg;
- stomach cramps, diarrhea that may be bloody;
- numbness or tingling in your fingers or toes;
- chest pain or tightness, shortness of breath;
- muscle pain in your arms or legs;
- leg weakness; or
- swelling or itching.
Common side effects may include:
- pain, bruising, swelling, or irritation where the medicine was applied;
- sleep problems (insomnia);
- dizziness;
- nausea, vomiting, diarrhea;
- runny nose;
- altered sense of taste; or
- soreness or irritation in your nose.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Pregnancy & Breastfeeding
Can I take Migranal (Dihydroergotamine Injection) if I’m pregnant or breastfeeding?
Dihydroergotamine can affect blood circulation to your uterus. Tell your doctor if you are pregnant or plan to become pregnant. Do not use this medicine if you are pregnant.
Do not breastfeed while using this medicine, and for at least 3 days after your last dose. Talk with your doctor about the best way to feed your baby.
Interactions
What drugs and food should I avoid while taking Migranal (Dihydroergotamine Injection)?
Do not use dihydroergotamine nasal within 24 hours before or after using another migraine headache medicine, including:
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Grapefruit may interact with dihydroergotamine nasal and cause side effects. Avoid consuming grapefruit products.
Dosage Guidelines & Tips
How to take Migranal (Dihydroergotamine Injection)?
Use Migranal (Dihydroergotamine Injection) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Dihydroergotamine nasal spray is absorbed quickly through your nasal passages and is for use only in the nose. The nasal spray liquid should not be injected into the body.
Your doctor may want to give your first dose of this medicine in a medical setting to quickly treat any serious side effects that occur.
You may need medical tests to check your heart function.
Store at room temperature away from moisture and heat. Do not keep this medicine in a refrigerator or freezer.
A Trudhesa vial should be thrown away 8 hours after it has been opened.
Dihydroergotamine is used when needed. If you are on a dosing schedule, skip any missed dose. Do not use two doses at one time.
Do not use more than 2 doses of Trudhesa within 24 hours or 3 doses within 7 days.
Do not use more than 3 mg of Migranal within 24 hours or 4 mg within 7 days.
Overdose Signs
What happens if I overdose on Migranal (Dihydroergotamine Injection)?
(800) 222-1222
911