Lumateperone (Caplyta) – Side Effects, Interactions, Uses, Dosage, Warnings

Side Effects

What are the side effects of Lumateperone (Caplyta)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

People with depression or mental illness may have thoughts about suicide. Some young people may have increased suicidal thoughts when first starting a medicine to treat depression. Stay alert to changes in your mood or symptoms. Your family or caregivers should also watch for sudden changes in your behavior.

High doses or long-term use of lumateperone can cause a serious movement disorder that may not be reversible. The longer you use lumateperone, the more likely you are to develop this disorder, especially if you are a woman or an older adult.

Call your doctor at once if you have:

• feeling unsteady, feeling like you might pass out;
• uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);
• tightness in your neck or throat, trouble swallowing;
• trouble breathing or speaking;
• a seizure;
• high blood sugar–increased thirst, increased urination, dry mouth, fruity breath odor;
• low white blood cell counts–fever, chills, mouth sores, skin sores, sore throat, cough, trouble breathing; or
• severe nervous system reaction–very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.

Common side effects may include:

• weight gain;
• nausea;
• dizziness;
• drowsiness; or
• dry mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.