Lomitapide (Juxtapid) – Side Effects, Interactions, Uses, Dosage, Warnings

You should not use lomitapide if you are allergic to it, or if:

• you have severe liver disease;
• you have abnormal liver function tests; or
• you are pregnant.

Many drugs can interact and cause dangerous effects. Some drugs should not be used together with lomitapide. Your doctor may change your treatment plan if you also use:

• aprepitant;
• conivaptan;
• crizotinib, imatinib;
• nefazodone;
• an antibiotic–ciprofloxacin, clarithromycin, erythromycin, telithromycin;
• antifungal medication–fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole;
• heart or blood pressure medicine–diltiazem, verapamil;
• hepatitis C medication–boceprevir or telaprevir; or
• HIV or AIDS medicine–atazanavir, darunavir when given with ritonavir, fosamprenavir, indinavir, lopinavir, nelfinavir, ritonavir, saquinavir, tipranavir.

Tell your doctor if you have ever had:

• liver problems, even if caused by taking certain medicines;
• kidney disease (or if you are on dialysis);
• bowel problems, or an intestinal disorder;
• hereditary galactose intolerance, severe lactase deficiency, or glucose galactose malabsorption; or
• if you drink large amounts of alcohol.

You may need to have a negative pregnancy test before starting this treatment.

Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. Lomitapide could harm the unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine.

If you become pregnant, your name may be listed on a pregnancy registry to track the effects of lomitapide on the baby.

Birth control pills may be less effective if you vomit or have diarrhea. Ask your doctor about the best way to prevent pregnancy while taking lomitapide.

You should not breastfeed while using lomitapide.

Lomitapide is not approved for use by anyone younger than 18 years old.